The Benefits and Functions of Cornmint Oil - Look Chemical

When used externally, cornmint oil can anesthetize nerve endings and stimulate cold receptors in the skin to produce a cold sensation. Fifty-two patients who received radiotherapy after radical surgery for breast cancer were divided into an observation group and a control group. The observation group applied compound menthol (menthol 2 g, starch 98 g) on the radiotherapy site at the same time as the radiotherapy. Used once, the control group did not use any drugs. Results The incidence rate of skin radiation reactions in each radiation field of patients in the observation group was significantly reduced, but the order and time of occurrence of radiation reactions were the same as those in the control group.

Taking a small amount of cornmint oil orally can stimulate the central nervous system, dilate skin capillaries, promote sweat gland secretion, increase heat dissipation, and have diaphoretic and antipyretic effects. However, it has been reported that menthol can enhance the central inhibitory effect of sodium pentobarbital, and has a certain dose-effect relationship. Intragastric administration of 0.9g/kg body weight of menthol can shorten the sleep latency of mice induced by sodium pentobarbital, but has no significant effect on the duration of sleep. However, intragastric administration of menthol at 0.3g/kg and 0.1g/kg body weight had no significant effect on shortening the time it takes for mice to fall asleep induced by sodium pentobarbital. The essential oils of mint and peppermint from the same genus both have central inhibitory effects. Intraperitoneal injection of 0.05g/kg body weight can significantly prolong the sleep time of mice induced by sodium pentobarbital. Cornmint oil also has weak anti-inflammatory and analgesic effects. Peppermint oil 120 mg/kg body weight orally administered by gavage has a certain inhibitory effect on carrageenan-induced foot swelling in rats, but the effect is weak and only lasts for 1 to 2 hours; p-xylene causes ear swelling in mice and There is no obvious inhibitory effect on the proliferation of cotton ball granuloma; it has no obvious effect on the latency of the nociceptive response caused by warm bath in mice, but it can inhibit the writhing reaction of mice caused by acetic acid, with an inhibition rate of 20% to 39%.peppermint oil

Cornmint oil has anti-early pregnancy and anti-implantation effects on mice and rabbits. On the 6th day after pregnancy in mice, 4 μl of peppermint oil was injected into the right uterine horn. An autopsy was performed on the 11th day after pregnancy. It was found that the ovules were necrotic and the pregnancy termination rate was 100%. Intramuscular injection of peppermint oil once on the 4th to 10th day after pregnancy also has a certain anti-early pregnancy effect, and it is dose-related. The anti-implantation rate reaches 100% at a dose of 0.035 m1/animal. Reasons for termination of pregnancy may be related to increased uterine contractions or direct damage to the decidual tissue. On the 6th or 9th day after pregnancy, Japanese big-eared white rabbits were injected with 0.5 ml of peppermint oil diluted with 40% olive oil into the free end of the right uterine horn and the proximal end of the right uterine horn, and were sacrificed on the 12th day, and the dosage was determined. estrogen, progesterone and human chorionic gonadotropin HCG before and before sacrifice. Results There was no significant difference between the levels of progesterone and estradiol in plasma before administration and before sacrifice compared with the control group, but the level of HCG decreased significantly. Microscopic observation of drug-administered tissue sections revealed that the rabbit embryos had varying degrees of degeneration and necrosis, among which the trophic leaves were significantly degenerated and necrotic. It shows that the mechanism of peppermint oil’s effect on terminating early pregnancy and resisting implantation in rabbits may not be related to uterine contraction, but mainly related to damage to vegetative leaves. For the isolated uterus of rabbits and guinea pigs, peppermint oil and its main component menthol have obvious inhibitory effects on the tension, strength, and strength-tension difference.

Cornmint oil administered into the duodenum at 120, 60, and 30 mg/kg body weight has obvious choleretic effects on rats and can slightly increase the excretion of bile acids in bile. Menthol administered to rats at 260 μmol/kg body weight also had a strong choleretic effect. After menthol was given for 3-4 hours, bile excretion increased approximately 4 times, and then the effect weakened. However, in the in vitro stone dissolution test, peppermint oil 5, 0.5, and 0.05 mg/L had no obvious dissolving effect on cholesterol stones and bilirubin stones within 4 to 5 weeks. In vitro, cornmint oil and its main component menthol have a significant inhibitory effect on the tension, intensity, and intensity-tension difference of ileal activity in rabbits and guinea pigs, and can resist the effects of histamine, acetylcholine, barium chloride, etc. Intestinal hyperactivity.

Using the abdominal and dorsal skin of fetuses with a gestational age of 7 to 8 months as a transdermal absorption experimental model, 1%, 2.5%, and 5% menthol can significantly promote the transdermal absorption of acetamidoethylphenol. The mechanism is related to the skin related to ultrastructural changes. A transdermal absorption experimental model was made using nude mouse skin. Menthol was added to 5% acetaminophen solution to make the menthol concentration reach 2.5%. It was added from the administration pool and sampled from the receiving pool for measurement. The results showed that menthol can significantly promote the transdermal absorption of acetaminophen, its penetration-assisting effect increased significantly 2 hours after administration, and its intensity continued to increase with time. Menthol can promote the transdermal absorption of tetracycline, rifampicin, lincomycin, griseofulvin, metronidazole, and clobendazole, and there is a dose-effect relationship. The skin penetration-promoting effect of 3.0% menthol is related to There was no significant difference between 2.0% laurelchlordone. Intragastric administration of 10% menthol paraffin oil at 15 m1/kg body weight can significantly extend the half-life of the distribution phase of sulfadiazine in rats and increase the concentration of sulfadiazine in the brain of rats; intragastric administration at 0.5g/kg body weight can also promote the development of sulfadiazine. Vince blue penetrates the blood-cerebrospinal fluid barrier in mice.

The stimulating effect of menthol causes new secretions in the trachea, making thick mucus easier to expel. Inhalation of menthol vapor in anesthetized rabbits at 81 mg/kg body weight can increase respiratory mucus secretion and reduce the specific gravity of secretions; however, inhalation of 243 mg/kg body weight can reduce mucus discharge, which may be a direct effect on respiratory mucus cells. When menthol is used for bronchitis, it can reduce foamy sputum in the respiratory tract, increase the effective ventilation cavity, and exhibit an expectorant effect.

Cornmint oil and menthol are in a closed system with Sclerotinia sclerotiorum, Rhizopus stoloniferum, and Mucor fungus respectively, and can inhibit the growth and reproduction of these fungi in a dose-dependent manner, while menthone has no such effect. In in vitro plaque inhibition experiments, peppermint oil showed strong inhibitory effects on the two subtypes of herpes simplex virus, HSV-1 and HSV-2, with IC50s of 0.002% and 0.0008% respectively.