Chromium nicotinate CAS 64452-96-6

Chromium Niotinate: Physiological effects, applications and uses

1. Chromium Nicotinate and the Human Body

1) Activate Insulin and promote glucose metabolism

Insulin is responsible for transporting glucose and amino acids to cells, binding with insulin receptors located on cell walls, and generating energy that promotes tissue growth, repair and regeneration. Chromium nicotinate stimulates beta-cells and attaches itself to cells. This forms a complex ternary of chromium and insulin receptor. As a result, chromium acts as a cofactor and enhancer for insulin. Only biologically active Chromium Nicotinates, such as GTF (chromium picolinate), Chromium Nicotinate, and Chromium Picolinate can activate insulin to achieve glucose metabolism. Chromium nicotinate deficiency in the body can lead to intolerance of glucose (reduced tissue sensitivity to it), which manifests as increased insulin and blood sugar levels. Diabetes can result from severe cases. Due to the absence of chromium, insulin secreted by suffering cannot be activated or bind to insulin receptors within cells.

2) Treat and prevent cardiovascular disease by reducing total cholesterol levels in the blood

According to a survey, patients with coronary heart disease have lower serum chromium levels than those without obstructed arteries. A Chromium Nicotinate Deficiency can trigger insulin resistance and arteriosclerosis. The pancreas produces insulin during carbohydrate metabolism. When consuming a lot of monosaccharides the pancreas needs to secrete more insulin. The pancreas secretes more insulin when insulin is not working properly due to lack of active chromium. As insulin secretion increases, Chromium Nicotinate consumption and chromium excretion through urine increase, resulting in a loss of chromium over time and insulin resistance. In many healthy people without diabetes who do not have high levels of insulin and are not overweight, but have normal glucose tolerance, they have low levels (HDL) of high-density Lipoprotein, which is good for the body, while high levels (LDL) of LDL is bad. These individuals also have high blood pressure and total cholesterol. Insulin resistance increases the risk of heart disease by two times compared to normal people. A lack of Chromium Nicotinate causes insulin to lose its biological effect. It also affects glucose metabolism and increases cholesterol biosynthesis. This leads to excess blood cholesterol and accelerates atherosclerosis.

3) Chromium Nicotinate Promotes Weight Loss and Muscle Growth

Insulin resistance is common in patients with obesity or autoimmune disease. This refers to an increase in insulin receptor sensitivity that controls metabolism, due to a chromium shortage. It leads to an increase in fat storage, as excess carbohydrates are converted into fat. When there is sufficient active chromium, the muscles and organs become more sensitive to insulin. Insulin can then better convert excess fat and glucose into energy.

2. Chromium Nicotinate is used in the production of livestock and poultry.

Chromium Nicotinate is becoming more and more popular as a feed ingredient in recent years. Chromium Nicotinate is approved in many countries, including the United States and Japan. Chromium-nicotinate’s physiological effects on animals have also been studied more. Many reports have been published on the effects of chromium in animal production. The results of first-class research have shown that calves who are supplemented with 100 or 200 mg/kg of chromium gain more weight and consume more dry matter at an older age. Chromium Nicotinate is able to promote pig growth and improve the quality of pig meat. It can also increase sow farrowing rates, reduce piglet mortalities, and increase lean-meat percentage. In a study, adding chromium in chicken feed resulted in a decrease of cholesterol, lowered low-density cholesterin, and increased egg production. Chromium is able to boost the immune system in stressed cows.